abstract：:Angiogenesis is critical for re-establishing blood supply to the ischemic myocardium after acute myocardial infarction (AMI). This study aimed to investigate the effects of morroniside on angiogenesis after AMI and explored associated proangiogenic mechanisms. A rat model of AMI was established by ligation of the left...

journal_title：European journal of pharmacology

authors： Liu T,Sun F,Cui J,Zheng S,Li Z,Guo D,Tian X,Zhu Z,Zheng W,Wang Y,Wang W

更新日期：2020-04-05 00:00:00

abstract：:Bitter taste receptors (Tas2rs) initiate a bitter taste signaling involving the activation of taste-specific G protein gustducin and phosphodiesterases (PDEs); it leads to the decrease of cytosolic level of cyclic adenosine monophosphate (cAMP) in taste cells. Recent studies have identified the expression of Tas2rs in...

journal_title：European journal of pharmacology

authors： Liu M,Qian W,Subramaniyam S,Liu S,Xin W

更新日期：2020-04-05 00:00:00

abstract：:The humanized anti-CD52 antibody alemtuzumab is successfully used in the treatment of multiple sclerosis (MS) and is thought to exert most of its therapeutic action by depletion and repopulation of mainly B and T lymphocytes. Although neuroprotective effects of alemtuzumab have been suggested, direct effects of anti-C...

journal_title：European journal of pharmacology

authors： Ellwardt E,Vogelaar CF,Maldet C,Schmaul S,Bittner S,Luchtman D

更新日期：2020-03-15 00:00:00

abstract：:Macrophages play important roles in the healing and remodeling of cardiac tissues after myocardial ischemia/reperfusion (MI/R) injury. Here we investigated the potential effects of salvianolic acid B (SalB), one of the abundant and bioactive compounds extracted from Chinese herb Salvia Miltiorrhiza (Danshen), on macro...

journal_title：European journal of pharmacology

authors： Zhao M,Li F,Jian Y,Wang X,Yang H,Wang J,Su J,Lu X,Xi M,Wen A,Li J

更新日期：2020-03-15 00:00:00

abstract：:This review provides a comprehensive analysis of the anticancer potential of the natural product citral (CIT) found in many plants and essential oils, and extensively used in the food and cosmetic industry. CIT is composed of two stereoisomers, the trans-isomer geranial being a more potent anticancer compound than the...

journal_title：European journal of pharmacology

authors： Bailly C

更新日期：2020-03-15 00:00:00

abstract：:(25R)-spirost-5-en-3β-ol, also known as diosgenin (DSG), exerts antiproliferative activity on diverse cell lines, induces apoptosis, and acts as a chemopreventative agent. However, the relationship between DSG glycosides and apoptotic, necrotic, and antiproliferative activity remains unclear. It is in this regard that...

journal_title：European journal of pharmacology

authors： Hernández-Vázquez JMV,López-Muñoz H,Escobar-Sánchez ML,Flores-Guzmán F,Weiss-Steider B,Hilario-Martínez JC,Sandoval-Ramírez J,Fernández-Herrera MA,Sánchez Sánchez L

更新日期：2020-03-15 00:00:00

abstract：:The paraventricular nucleus of the hypothalamus (PVN) contains dense orexin 2 (OX2) receptor. We examined the mechanisms of OX2 receptor-mediated excitation on electrophysiologically identified type I (putative magnocellular), low-threshold spikes (LTS)-expressing type II (putative preautonomic), and non-LTS type II (...

journal_title：European journal of pharmacology

authors： Dai YE,Lee YH,Li TL,Hwang LL

更新日期：2020-02-15 00:00:00

abstract：:Airway remodeling in asthma is difficult to treat because of its complex pathophysiology that involves proinflammatory cytokines, as well as the arachidonic acid cytochrome P-450 (CYP) pathway; however, it has received little attention. In this study, we assessed the efficacy of a soluble epoxide hydrolase (sEH) on ai...

journal_title：European journal of pharmacology

authors： Jiang JX,Guan Y,Shen HJ,Jia YL,Shen J,Zhang LH,Liu Q,Zhu YL,Xie QM

更新日期：2020-02-05 00:00:00

abstract：:Hyperphosphatemia is a mineral bone-disease that increases cardiovascular complications and all-cause mortality in chronic kidney disease (CKD) patients. Oral phosphate binders absorb the dietary phosphate to prevent its high plasma levels. Moreover, they can adsorb some uremic toxins and decrease inflammation. A few ...

journal_title：European journal of pharmacology

authors： Rahbar Saadat Y,Niknafs B,Hosseiniyan Khatibi SM,Ardalan M,Majdi H,Bahmanpoor Z,Abediazar S,Zununi Vahed S

更新日期：2020-02-05 00:00:00

abstract：:Aspirin (acetylsalicylic acid), the oldest synthetic drug, was originally used as an anti-inflammatory medication. Being an irreversible inhibitor of COX (prostaglandin-endoperoxide synthase) enzymes that produce precursors for prostaglandins and thromboxanes, it has gradually found several other applications. Sometim...

journal_title：European journal of pharmacology

authors： Hybiak J,Broniarek I,Kiryczyński G,Los LD,Rosik J,Machaj F,Sławiński H,Jankowska K,Urasińska E

更新日期：2020-01-05 00:00:00

abstract：:Cancer remains a major public health problem worldwide and was responsible for 9.6 million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab (Trz) are chemotherapeutic drugs used to treat several types of cancer, including solid and non-solid malignancies. Although these drugs have a signi...

journal_title：European journal of pharmacology

authors： Prathumsap N,Shinlapawittayatorn K,Chattipakorn SC,Chattipakorn N

更新日期：2020-01-05 00:00:00

abstract：:Increasing costs, much time consumption and high risk of failure associated with the process of de novo development of new anticancer drugs have prompted the pharmaceutical industry to seek alternative strategies that may facilitate and accelerate the whole process. In particular, the repurposing strategy, known also ...

journal_title：European journal of pharmacology

authors： Antoszczak M,Markowska A,Markowska J,Huczyński A

更新日期：2020-01-05 00:00:00

abstract：:The present study has examined the antidiabetic effects of 21 days co-administration of xenin-8-Gln with the dual-acting fusion peptide, exendin-4/gastrin, as well as persistence of beneficial metabolic benefits, in high fat fed (HFF) mice. Xenin-8-Gln, exendin-4 and gastrin represent compounds that activate receptors...

journal_title：European journal of pharmacology

authors： Hasib A,Khan D,Craig SL,Gault VA,Flatt PR,Irwin N

更新日期：2019-12-15 00:00:00

abstract：:Acute kidney injury (AKI) is defined as a rapid loss of kidney function characterised by inflammation and cell death, ultimately leading to further functional and structural renal alterations. Based on experimental and epidemiological pieces of evidence, AKI may progress to chronic kidney disease (CKD) even after a re...

journal_title：European journal of pharmacology

authors： Ogbadu J,Singh G,Aggarwal D

更新日期：2019-12-15 00:00:00

abstract：:Nucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites-approved antin...

journal_title：European journal of pharmacology

authors： Pastuch-Gawołek G,Gillner D,Król E,Walczak K,Wandzik I

更新日期：2019-12-15 00:00:00

abstract：:Mitochondrial DNA mutations promote hypertensive renal dysfunction, but the molecular mechanism remains unclear. This study compared renal damage between spontaneously hypertensive rats (SHR) and SHR with mitochondrial transfer (t)RNA mutations. To investigate the role of mitochondrial outer membrane voltage-dependent...

journal_title：European journal of pharmacology

authors： Zhu C,Tian L,Yang H,Chen P,Li Y,Liu Y

更新日期：2019-12-15 00:00:00

abstract：:Family, adoption and twin studies have highlighted the significant role of heritable influences on individual differences in opioid addiction. Meanwhile, obsessive-compulsive disorder (OCD) is a disorder wherein the individual experiences recurring thoughts that cause irrational fears and anxiety. In the present study...

journal_title：European journal of pharmacology

authors： Rohbani K,Sabzevari S,Sadat-Shirazi MS,Nouri Zadeh-Tehrani S,Ashabi G,Khalifeh S,Ale-Ebrahim M,Zarrindast MR

更新日期：2019-12-15 00:00:00

abstract：:We determined the role of high-grade inflammation on endothelial function and its association with biomarkers of endothelial dysfunction in collagen-induced arthritis. Sprague-Dawley rats were divided into a control (n = 12) or collagen-induced arthritis (CIA; n = 21) group. To induce arthritis, Bovine-type-II collage...

journal_title：European journal of pharmacology

authors： Mokotedi L,Millen AME,Mogane C,Gomes M,Woodiwiss AJ,Norton GR,Michel FS

更新日期：2019-12-15 00:00:00

abstract：:Histone deacetylases (HDACs) can regulate cancer progression and its inhibitors (HDACIs) have been widely used for cancer therapy. Valproic acid (VPA, 2-propylpentanoic acid) can inhibit the class I HDAC and suppress the malignancy of solid cancers. Our present study revealed that 1 mM VPA, which has no effect on cell...

journal_title：European journal of pharmacology

authors： Zhang S,Tang Z,Qing B,Tang R,Duan Q,Ding S,Deng D

更新日期：2019-12-15 00:00:00

abstract：:To test the hypothesis that the flavonoid compound, fisetin, protects macrophages from lipid accumulation and senescence through regulation of casein kinase 2-interacting protein-1 (CKIP-1)/REGγ (11S regulatory particles, 28 kDa proteasome activator, proteasome activator subunit 3) signaling. RAW264.7 macrophage cells...

journal_title：European journal of pharmacology

authors： Jia Q,Cao H,Shen D,Yan L,Chen C,Xing S

更新日期：2019-12-15 00:00:00

abstract：:Type 1 diabetes (T1D) is a multifactorial autoimmune disease that develops as a consequence of macrophage- and T cell-dependent pancreatic β-cell death. Multiple approaches for induction of anti-inflammatory/regulatory mechanisms that would attenuate T1D have been utilized, with little or no beneficial effects. To ach...

journal_title：European journal of pharmacology

authors： Koprivica I,Gajic D,Saksida T,Cavalli E,Auci D,Despotovic S,Pejnovic N,Stosic-Grujicic S,Nicoletti F,Stojanovic I

更新日期：2019-12-01 00:00:00

abstract：:Dehydrocorydaline, is an active alkaloid compound in Corydalis yanhusuo W. T. Wang. We found dehydrocorydaline induced antidepressant-like effects in a chronic unpredictable mild stress mouse model, but the exact mechanisms have not been addressed. We speculated that dehydrocorydaline may have an antidepressant effect...

journal_title：European journal of pharmacology

authors： Jin L,Zhou S,Zhu S,Lei S,Du W,Jiang H,Zeng S,Zhou H

更新日期：2019-12-01 00:00:00

abstract：:Pulmonary arterial remodeling is a crucial cause of increased pulmonary artery pressure during pulmonary hypertension (PH). Recently, growing evidence has upheld the contribution of endothelial-mesenchymal transition (EndMT) to pulmonary arterial remodeling, but the underlying mechanisms remain largely unaddressed. mi...

journal_title：European journal of pharmacology

authors： Liu T,Zou XZ,Huang N,Ge XY,Yao MZ,Liu H,Zhang Z,Hu CP

更新日期：2019-11-15 00:00:00

abstract：:Corticotropin-releasing factor (CRF) plays an important role in sympathetic regulation. Centrally administered CRF elevates plasma catecholamine levels, resulting in CRF-dependent hypertension and tachycardia. We previously reported that brain thromboxane A2 mediates CRF-induced elevation of plasma adrenaline levels, ...

journal_title：European journal of pharmacology

authors： Yamaguchi N,Mimura K,Okada S

更新日期：2019-11-15 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Despite the impact of this pathology in the population, nowadays there is no specific treatment for this disease, focusing its treatment on risks factors. However, it is imperative the existence of a specific treatment, due to this...

journal_title：European journal of pharmacology

authors： de Jesús Acosta-Cota S,Aguilar-Medina EM,Ramos-Payán R,Rendón Maldonado JG,Romero-Quintana JG,Montes-Avila J,Sarmiento-Sánchez JI,Plazas-Guerrero CG,Vergara-Jiménez MJ,Sánchez-López A,Centurión D,Osuna-Martínez U

更新日期：2019-11-15 00:00:00

abstract：:Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in both 2-dimensional (2D) and 3-dimensional (3D) cell culture, we investigated the mechanisms of simvastatin's myotoxicity. W...

journal_title：European journal of pharmacology

authors： Emami A,Shojaei S,da Silva Rosa SC,Aghaei M,Samiei E,Vosoughi AR,Kalantari F,Kawalec P,Thliveris J,Sharma P,Zeki AA,Akbari M,Gordon JW,Ghavami S

更新日期：2019-11-05 00:00:00

abstract：:Bronchial and alveolar epithelial cell apoptosis is a vital step in smoke-induced lung injury. We investigated whether and how microRNA (miRNA) Let-7f-1-3p would regulate smoke-induced apoptosis in bronchial and alveolar epithelial cells. Human small airway epithelial cells (HSAEC) and human pulmonary alveolar epithel...

journal_title：European journal of pharmacology

authors： Han Z,Zhu Y,Cui Z,Guo P,Wei A,Meng Q

更新日期：2019-11-05 00:00:00

abstract：:Hepatic and systemic insulin resistance form the core of metabolic syndrome which is also associated with cardiovascular abnormalities, inflammation, and dyslipidemia. Skeletal muscles and adipose tissues are two main target organs for glucose disposal and hence have been studied for insulin resistance too. The liver ...

journal_title：European journal of pharmacology

authors： Patel BM,Goyal RK

更新日期：2019-11-05 00:00:00

abstract：:Lung cancer is a disease with increasing morbidity worldwide in recent years. Approaches such as chemotherapy and biological targeting for its treatment are urgently needed. Epithelial-mesenchymal transition (EMT) is an important initiation stage for tumor cells to acquire invasive and metastatic abilities. Increasing...

journal_title：European journal of pharmacology

authors： Guo L,Liu Z,Tang X

更新日期：2019-11-05 00:00:00

abstract：:Increased glycolysis under hypoxic stress is a fundamentally important feature of non-small cell lung cancer (NSCLC) cells, but molecular mechanisms of hypoxia on glycolysis remain elusive. Herein, we aimed to explore whether lncRNAs and miRNAs are involved in the glycolytic reprogramming under hypoxic conditions. The...

journal_title：European journal of pharmacology

authors： Shi J,Wang H,Feng W,Huang S,An J,Qiu Y,Wu K

更新日期：2019-11-05 00:00:00

abstract：:Increasing evidence displays that microRNAs (miRNAs) participate in the development of various human malignancies, including esophageal squamous cell carcinoma (ESCC). MicroRNA-33a-5p (miR-33a-5p) has recently been reported to function as a tumor suppressor in many human cancers. However, the expression and role of mi...

journal_title：European journal of pharmacology

authors： Zhang C,Wang L,Yang J,Fu Y,Li H,Xie L,Cui Y

更新日期：2019-10-15 00:00:00

abstract：:Alterations in iron homeostasis are well described in obese patients. The effects of iron chelators on adipose tissue and other organs affected by obesity have been the interest of experimental studies, both in vivo and in vitro. The aim of this review was to update the available information indicating the potential o...

journal_title：European journal of pharmacology

authors： Rodrigues de Morais T,Gambero A

更新日期：2019-10-15 00:00:00

abstract：:Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with additional antioxidant properties. Doxorubicin (DOX) is an anticancer drug that exerts oxidation-mediated adverse cardiovascular effects. This study examined the effects of nicorandil on DOX-induced cytotoxicity in human umbilical vein end...

journal_title：European journal of pharmacology

authors： Chen CC,Hong HJ,Hao WR,Cheng TH,Liu JC,Sung LC

更新日期：2019-09-15 00:00:00

abstract：:Diabetic cardiomyopathy (DCM) is one of the major cardiac complications in diabetic patients and a major reason for the death of diabetic patients. Obeticholic acid (OCA) is a semi-synthetic bile acid analogue. The objective of the present study was to investigate the possible cardio-protective effect of OCA against D...

journal_title：European journal of pharmacology

authors： Wu H,Liu G,He Y,Da J,Xie B

更新日期：2019-09-05 00:00:00

abstract：:Minocycline functions as a therapeutic drug in different diseases because of its cytoprotective properties. In the present study, we examined the potential of minocycline to decrease the islet loss in pre-transplantation culture stage. Pancreatic islets were isolated from the deceased donors and treated by 0, 2, 10, a...

journal_title：European journal of pharmacology

authors： Kaviani M,Keshtkar S,Azarpira N,Aghdaei MH,Geramizadeh B,Karimi MH,Shamsaeefar A,Motazedian N,Nikeghbalian S,Al-Abdullah IH

更新日期：2019-09-05 00:00:00

abstract：:A natural monoterpene alkaloid incarvillateine isolated from the plant Incarvillea sinensis is known to relieve inflammatory and neuropathic pain. However, the molecular target for the action of incarvillateine remains elusive. Here, we report that incarvillateine exacerbates epileptic seizures by inhibiting subtypes ...

journal_title：European journal of pharmacology

authors： Bian X,Zhang Y,Huang B,Wang X,Wang G,Zhu Y,Liu Y,Liang J,Jia Y,Wang K

更新日期：2019-09-05 00:00:00

abstract：:The extracts of Phellodendron amurense (P. amurense) have been shown to contain many active ingredients e.g. flavone glycosides and to exert a wide range of physiological activities including anti-tumor activity. However, the effects of phellamurin (Phe), a plant flavonone glycoside from the leaves of P. amurense, on ...

journal_title：European journal of pharmacology

authors： Zhang H,Jiang H,Zhang H,Liu J,Hu X,Chen L

更新日期：2019-09-05 00:00:00

abstract：:Lipoprotein lipase (LPL) is the rate-controlling enzyme for the accumulation of triacylglycerol into adipocytes, which acts by digesting it into glycerol and fatty acids. In this study, we found that treatment with (+)-JQ1, an inhibitor of the bromodomain and extra-terminal (BET) family proteins, for 4 days from the e...

journal_title：European journal of pharmacology

authors： Inoue T,Hariya N,Imamochi Y,Dey A,Ozato K,Goda T,Kubota T,Mochizuki K

更新日期：2019-09-05 00:00:00

abstract：:Breast cancer is one of the main diagnosis cancers annually worldwide. It is difficult to thorough cure due to drug resistance and the high possibility of metastasis. SM934 is a novel water-soluble artemisinin analog, and has been reported to have a promising therapeutic effect on multiple autoimmune diseases. In this...

journal_title：European journal of pharmacology

authors： Gu X,Peng Y,Zhao Y,Liang X,Tang Y,Liu J

更新日期：2019-09-05 00:00:00

abstract：:Lipopolysaccharide (LPS) increases inflammatory cytokines of the brain and deregulates the mitochondrial function, thus could increase the seizure susceptibility. Studies have shown that minocycline has neuroprotective and antioxidant properties. In this study, we aimed to evaluate the anticonvulsant properties of min...

journal_title：European journal of pharmacology

authors： Haj-Mirzaian A,Ramezanzadeh K,Tafazolimoghadam A,Kazemi K,Nikbakhsh R,Nikbakhsh R,Amini-Khoei H,Afshari K,Haddadi NS,Shakiba S,Azimirad F,Mousavi SE,Dehpour AR

更新日期：2019-09-05 00:00:00